IMO the Big12 is in a sit back and wait position for the Big10 and SEC to create 2 super conferences aligned with Fox (Big10) and Disney (SEC).
If each super conference is 20 teams (4 - 5 team divisions), then the SEC needs 4 teams and the Big10 needs 6 teams.
So Iowa State will need to wait and see how HOT the SEC and Big10 view the Cyclones.
On the hotness scale, I would go:
10's - Notre Dame & Clemson.
9's - North Carolina & Virginia.
8's - Okie St (SEC), FSU, Miami.
7's - NC State, GA Tech, IA State.
That's 10 teams for 10 spots. The wildcards:
1) Can the Big10 or SEC make Pac12 schools work. If they want the Pac12 schools then I think ISU is definitely in the outside I think ISU is in a conference with Big12, ACC and Pac12 remnants.
2) How loyal are the SEC and Big10 to existing members? Do Rutgers, Vandy, etc. have a place at the table?