Another one: pei wei
Titled Kilt... decent food fantastic scenery!
Five Guys (hamburger and fry joint)
I don't eat fast food, but if there was an IN-N-OUT Burger in Des Moines I would probably be pushing up the percentage of obese Iowan's.
How about a cold stone creamery by bass pro in Altoona?! Altoona only has a DQ on the other side of town...
Many of the chain restaurants being mentioned require a TON of capital and/or net worth...in the millions of dollars.
I love the Tasty Tacos idea. That would kill in campustown.
Iowa City has one of these but I bet it would go over well in Ames or Des Moines: Steak 'n Shake
The other place I'd look at is Jersey Mike's Subs. May not run Jimmy John's out of business, but it would put the hurting on Subway and Quiznos.
Jersey Mike's Subs - Authentic Sub Sandwiches Since 1956
That place would probably fit more on Duff, though. IMO Campustown would need a place that would be able to stay open late and serve a lot of drunks quickly. Burritos, gyros, subs, pizza by the slice. The one exception would be a sportsbar type place that serves food AND beer (BWW). It sounds like there should be some strip mall type places being built on Duff (in front of Target) that would be perfect fits for places like Noodles Etc, Jersey Mike's, Five Guys...fast casual.