I really like Big Bang theory. No offense to any of the haters, but I think that the more math/physics you've taken the funnier it is. As a grad student in a hard science, I find that the show hits a very genuine cord and that many of the science jokes are hilarious.
If you're not a big math/science guy and have never had any friends who are DEEP into sci-fi, I can see where the show would seem irritating.
I almost feel the opposite about Big Bang Theory. I like the show and it has its good moments, but half the jokes honestly show the writers' limited knowledge. For example, why is Wollowitz working at the university as an engineer with a masters? Engineers don't work for universities unless they are PhDs who are teaching and doing research. He does neither. To me, the harder they try to make it sound like these guys represent the real thing, the worse they are. It's better if they just stick to the stereotypes and make it clear they aren't thinking too deeply.
Also, if someone could ban the word "coitus" from the ****** I would really appreciate it.