As has been noted, Iowa State looked tired going into the Camping World Bowl. It had been a tough season (for example, Eisworth playing injured the whole year). I'm going to be nervous as heck going into this one but do know that CMC and his staff know how to overcome many things.Indiana as a program is way too much of a question mark for the premise of this thread.
If Iowa had just soundly beat Ohio State or even Wisconsin I'd give the OP's premise some serious consideration. They looked great. We don't know how good Indiana is.
I do think that ND team was a tougher matchup than the recent wins and close losses vs OU we've had.