If you're going to talk like you have all the answers from your second hand anecdotal evidence I just thought it would be good to be accurate.
Ozempic, GLP-1 and other modern diabetes / weight loss medications
- Thread starter ISUCyclones2015
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Quick google says that generic versions of Ozempic cannot be sold until 2032 because of patent protection, at least here in the US.
Second-hand but also why does it matter if they hit "the easy button"? You want people to lose weight but oh, no not like that. Why do you care if other people make different choices than you? Lot of men hit "the easy button" via a blue pill in middle age too. People hit the easy button on wrinkles. I'm curious if you direct this level of derision there or at anyone drinking alcohol. Lot of risk there too.
I'm in the middle on all this, but I do know one person who got on this for legit A1C/Diabetes, and she has had some side effects:
#1, GI impacts. She basically had so much stomach upset that she could barely eat the first several months. Like a few bites and she was ill and couldn't eat. She wasn't hungry, just felt nauseous. And lots of unpleasantness in the bathroom. This has got better over time, but still exists.
#2, she got drop-foot. I'm not exactly sure the mechanism (muscle loss?), but it impacted her nerves in one knee. But she was tripping a lot, it was causing her a lot of leg/knee pain, had trouble walking, and it took a while to figure out the cause. She had to do a bunch of PT and it's OK now.
#3, she lost a TON of muscle and strength. This is a lady pushing 60, probably about 5'4" and maybe 160lbs at the beginning (I am guessing, a gentleman doesn't ask lol). She is a biker, and never had any issues handling her HD Deluxe, which is a decent side bike. Well, now she probably weighs like 120lbs and has dropped her bike a couple times because she has just lost a lot of muscle. She looks like she's wasting away, imho, but I think she is adjusting.
So let's not pretend there are no side effects. My understanding is maybe half of people on these get the GI impacts to some level or another. But despite all the above, she has stayed on it, and it has controlled her diabetes issues. TANSTAAFL.
#3 is the reason we can't just be handing these out to people without supervision. People need to account for this and adjust their diet and make sure they're resistance training. Whenever people lose weight their will be muscle loss but it can be minimized.
Otherwise I have zero issues with people utilizing these drugs to lose weight.
You have to be under a doctors care to be on the drug, so that should not be an issue. Is this a wonder drug, I have no clue, I just know it works for me, and I have few to no side effects. I feel better, love that cloths now fit comfortably. My biggest complaint would be I still struggle ordering less food, than I did before. But even that is improving, we went down to Polk City for pizza last week, I ate a couple pieces of pizza, and we took the rest home with us to eat the next day. Before I was on the drug, I would have eaten 4 or 5 pieces.
Answers to what? Sharing the fact that of the dozen people that I KNOW that have gone on these shots ONLY 1 of those people made any changes to their daily habits before going on them?
It's called sharing a personal experience. In any of my post did I say ALL PEOPLE? or Everyone?. It's no different than the poster who shared their story of how much it has helped them. That's awesome, and happy that it has made their life that much better.
Anytime, no matter how you do it, if you lose weight fast, a high amount will be from muscle mass. Even if you do it with just diet and exercise, the general rule of thumb is you can drop about 2 pounds a week before you start losing hard muscle mass.
Except that's their own story, not the story of 12 other people. Maybe you do know the day to day diet history of 12 other people, maybe that's totally normal and I'm just not aware.
It's also called first hand vs second hand knowledge, and your accounts are second hand, not first.
I do not care if they hit the easy button or not and I don't care if they want to lose weight or not what a weird thing to say. The discussion was about potential side effects from these drugs and pointing out the fact that those potential side effects could have ended up not being a concern if they maybe first tried to change some daily habits. They might have found those changes to work... or they might not have who knows in which case they would have been like the 1 person who did try to make those changes and ended up using it to help them.
Next thing wtf are you even talking about with those other things? What do they have to do with anything about potential side effects from these drugs?
No but it isn't hard to ask them questions and find out. I know wild right? Having actual conversations with people to learn stuff.
Congrats this has now been said multiple times.
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Sort of like the opposite when it comes to putting on weight... certain limit of what can be muscle vs water/fat?
I always love people who think it's just this simple.
Most people who are on these have tried before. They may have even been successful before and gained it back. Many multiple times. Weight loss is pretty personal though so many may not have even told you they were making those efforts.
What we are learning is that for most people with a good amount of weight to lose it isn't just some issue with willpower or needing to do simple tricks to lose weight. Instead it's more likely they have hormones from their fat cells screaming at them to eat (Aka "food noise"). And those cells stick around even after weight loss. Glp-1 drugs like semaglutide/tirzepatide/retatrutide all help quiet those signals. You may not get those signals and that's why you think it's just a matter of making better decisions, but thats the thing - these drugs let everyone experience what is already just normal for you. Its not an "easy button", it's a treatment for a medical condition. Once people get that treatment, it is much more possible to then do the work
I cannot speak for others, only myself, but I have personally lost a little over 45 pounds on Ozempic, not only that, I have changed my eating habits because of the drug. I rarely drank soda before, I started using it, the big change I see is that I just consume less. I am not hungry, like I said earlier, a. couple pieces of pizza and I was full, and saw no need to eat more. Truthfully I cannot remember the last time I finished a meal when we go out. We end up taking a lot home to generally after sitting in the fridge for a day or two gets thrown away.
Before I started the drug I was riding my stationary bike 10 miles a day, and had lost only 5 to 10 pounds, generally after riding I would consumer more because I was burning more calories, I do not do that on the drug. My drinking level has also gone down while on the drug, I would drink 4 to 6 beers a night, now it's one or two. It works for me, and that is all I care about.
Before I started the drug I was riding my stationary bike 10 miles a day, and had lost only 5 to 10 pounds, generally after riding I would consumer more because I was burning more calories, I do not do that on the drug. My drinking level has also gone down while on the drug, I would drink 4 to 6 beers a night, now it's one or two. It works for me, and that is all I care about.
All this arguing boils down to "don't let the perfect be the enemy of the good". Eating well and exercising is ideal (at any weight), but the side effects are less bad than being obese.
(people w/ diabetes excepted)
(people w/ diabetes excepted)
My mother-in-law tried a GLP-1 but couldn’t handle the side-effects. She had diarrhea for almost three months before she gave up. She has struggled with weight for years and lots of yo-yo dieting.
All I got is a few anecdotes:
My overweight borderline T2D bro took it, was losing weight, but stopped because he was puking so much.
My T1D sis takes it, has lost lots of weight, seems to be doing well on it. She loves that she looks great.
My other sis, obese, takes it, still loves a super-rich diet, has lost a bit of weight. Her hubby, who has coronary artery disease, takes it and has lost a lot of weight and is doing well on it.
My overweight borderline T2D bro took it, was losing weight, but stopped because he was puking so much.
My T1D sis takes it, has lost lots of weight, seems to be doing well on it. She loves that she looks great.
My other sis, obese, takes it, still loves a super-rich diet, has lost a bit of weight. Her hubby, who has coronary artery disease, takes it and has lost a lot of weight and is doing well on it.
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Just wait until we start adding myostatin inhibitors and activin-A inhibitors in addition to GLP-1s. We will have a bunch of people walking around looking like bodybuilders.
Same with me. A1c was not high enough, but down 17 pounds and blood work is better than I was 30. It appears my cost is going to settle in at $400-$500 a month.
Be curious if the ones with more side effects were on semaglutide (wegovy/ozempic) or tirzepatide (zepbound/mounjaro).
Seems like tirz tends to have fewer. It hits the glp-1 receptor a little less hard than sema does I think but hits the GIP one alongside it, making it overall more effective. Worst I've had on tirz was some constipation, have to make sure I'm up on my fluids. (I'm down almost 60 since January on it)
