Hopeful prediction: ISU keeps their Big12 play going. Gets out to an early 6 pt lead halfway through the first. Endures some KU runs that have them taking the lead back. ISUs physicality and timely shooting secure the W with no funny stuff from the refs. ISU wins by 2.
Very well could happen: ISU shuts down KUs main players, one of their unreliable bench players comes in and puts up 16-20, a late banked three and a questionable call give KU a 4 pt win.