A lot of this just depends on how deep you're willing to dig. If you check out the indie scene in almost every genre (rock, hip hop/rap, etc.), you'll find some phenomenal acts. Kings of Leon were mentioned in this thread - they're a great example. They're a raw, scuzzy-sounding throwback band that's starting to get some cred - and their old stuff is better than the new. If you like hip-hop, try the Cool Kids. All you have to do is look a little deeper.
On that note... while I enjoy Foo Fighters, they are absolutely nothing extraordinary. Dave Grohl is so talented, but if one of your biggest songs ("Learning to Fly") was used as the theme song for "Sabrina, The Teenage Witch," you're a long ways from the anti-establishment band that started your career. I wish they'd go back to when they first started and were offbeat/bizarre - now it just seems so mass-produced and personality-free.
