While the formations of this offense are pretty wild, you still have to follow the basic rules of football, so they have to have 7 players on the line, meaning 5 players are "covered up" and thus ineligible to be downfield on passing plays. And since someone has to throw the ball, that leaves 5 players eligible to receive a pass. So the passing attack of this offense wouldn't be much different than a team running the spread or run-n-shoot, but there are variety of other plays that could be run utilizing backward passes, pitches, laterals, etc. As someone else stated, the main advantage you would have is the unknown. That and you create a lot of one-on-one matchups. An athletic defense that can tackle would probably handle this offense without a lot of difficulty. It would remind me a lot of playing Texas Tech.