After sleeping on it, I still think Sweet 16 (my vote yesterday) is possible, and as others have pointed out, anything after that takes some good breaks, both matchups and in-game.
What's top of mind this morning is, sure, Lipscomb's not a great matchup, but how in the world are they going to guard Jones and Momcilovic? I recognize Iowa State's defense could come out sluggish, and we've seen how quickly a team that likes to shoot can jump on an Otz defense. But I think ISU could potentially outscore them if all else fails, and FWIW I do not foresee a lack of defensive intensity after a week off. If they win and play Ole Miss or San Diego State, neither is highly skilled. So, not an awful matchup. I've watched Michigan State more the last few weeks than I did all season. They're extremely well-coached and are unique in that they have four good guards. But only one of those is skilled, and they don't shoot it well as a team. So again, Otz can live with a rock fight vs. a shootout. I wouldn't be shocked if Lipscomb makes 14 3s and wins. But I think the draw and the buy-in/certainty that comes with announcing Gilbert out, plus the fact that Otz can go full Campbell with "Nobody believes in us," are reasons for hope