Major bump here, just wanted to thank everyone for the input.
After a little consideration, I accepted the new job. Money has never been very important to me, and settling in will finally give me and my SO a chance to start a family (We're starting with a dog, suppose we should figure out if we can handle that first

). Plus, I won't be moving around so we are considering making he investment into buying a house. Appreciate all of the input people gave.
RE: Take home pay as mentioned. Don't know how the tax bracket will effect this, but since I'm switching fields, my take home pay rate will increase based on retirement contributions. Essentially, my previous job I was taking home similar money to what I would be making 69-70k at this new one. Yes, that means my retirement from that will not be as good, but I've been doing a lot on my own to plan for that, so I'm not worried.