Wow. Ohio State swallowed the hook on that one. You could tell they were clueless throughout. Baker Mayfield, since being referred to as the next Johnny Manzel, kept the ball hidden with his shoulders slumped. Simultaneously, the blocking back, Flowers, position blocked the DE, who, like the LBs, were completely focused on RB Sermon. When Flowers slid off, he remained completely unnoticed. Again, simultaneously, Mayfield, in one motion, raised up and hit Flowers on the run 7 yards behind the line of scrimmage. At full speed, it actually looks like a jump pass, but he never left his feet - no wasted motion whatsoever. Definitely play calling genius, but I assume a lot of things happened to set it up. For instance the DBs are all protecting the deep routes, and Sermon, up to that point, probably proved to be more formidable than anticipated.
So, if ISU tried this, the receivers who definitely take the DBs out of range. Montgomery is the best out of the backfield, but being the most fearsome RB, he would have to execute the fake. Otherwise, the LBs would not bite. So who would be the blocking back? If you want max YAC, it would need to be Mike Warren. But for the play to even work, you have to sell the whiff. So maybe it would need to be Sam Seonbuchner. But if he is too "hands of stone" to pull that off, a TE might be ideal in this hybrid role. Otherwise, it seems ISU rarely lines up with 2 RBs, and it would tend to alert the defense that something is up.