My favorite sequence in the modern era of ISU football is getting a couple of first downs on good looking plays or an explosive play to get in or close to the red zone, and the first play is a play clock draining cadence with 2 or 3 motions, off tackle run play.
It's only fair to let the defense get settled in and catch their breath.
Don't undersell the big play, followed by a fast tempo no huddle play that has the defense scrambling to get into position... which is always a plain vanilla handoff up the middle.