The optimistic side of me has been hearing things like "other conferences banding together against the SEC" and "JP leader of the NACDA" and this makes me think the following is possible:
Pac12 and B1G agree to an alliance to counterweight ESPN/SEC. As part of that, both go to 16 teams, providing a home for 6 of the Hateful8, which provides content, geography from sea to shining sea, and some godshonest solidarity with the Hateful 8.
This alliance would comprise just over half of the P5, and 70% of the AAU schools in P5, so you can really claim the COLLEGE and STUDENT-athlete high ground for marketing. You also have a good shot to bring the ACC (or most of it) into the fold at some point via an alliance in the future.
And in this, ISU would probably get put in the B1G with Kansas. You'd get some protected rivalry games with Okie St and KSt (now in the Pac12) which would be great. This is like absolute best case scenario for ISU, but I don't think its impossible.