Help! I'm Fat - *** Official Exercise and Weight Thread ***
- Thread starter cyclone4L
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Metformin is a powerful drug. The potential side negative side effects of this vs. Ozempic are much higher. No, I am not a dr, but ask a Dr to compare the two.
BMI is based strictly on height and weight - it doesn't do anything to account for lean/fat mass percentage. So if you're losing weight, your BMI is going down.
There aren't any really great ways to measure lean mass outside a medical setting. The impedance can be way off from an absolute accuracy standpoint, and probably isn't accurate enough to measure small changes day-to-day.
As a diabetic on Ozempic, I would think you'd go back to gaining weight once your off of it if you don't make lifestyle changes. Because Ozempic replicates a peptide that makes you feel full when eating, when actually eat, the medication in your body fills the space of receptors that your body would have naturally made during your eating process that your full. Once that supplemental medication goes away, your body then goes back to relying on making the peptides naturally, so you'd probably go back to your old ways.
I take the medication once a week and find that as I get towards the end of the week, I am eating a little more than I did at the beginning of the week. I assume this is because of the medication wearing off prior to my next dose.
Nah that’s the right way to go. If you’re on a drug the goal should always be (when possible) to fix the underlying issue to go off of said drug. Again not always possible or even advisable but should be a goal for the majority of prescriptions.
For the upcoming and current weight loss drugs that is incredibly tricky because as others have stated if you go off all of the progress is going to go backwards. But for people that have struggled with weight and have tried a lot of things it could be the best option for a number of reasons.
Studies also show a loss in muscle mass and bone density, including an increased risk for sarcopenia.
It doesn't mean people shouldn't use it, especially if obese. But people need to be conscious of the rate at which they are losing weight and make sure to supplement with protein, etc. People also need to be fully educated that if they stop the drug they'll gain the fat back.
Media and doctors are certainly telling people that once off the drugs people tend to gain the weight back. That's true, but that's not really the full story. For most people when they stop they gain the fat back, but not the lost muscle. For most people if you take the drug, then stop, they will end up with a worse body composition then they started with.
There are risks when on it, and most likely it's going to be a drug for life.
Anti‐diabetic drugs and sarcopenia: emerging links, mechanistic insights, and clinical implications - PMC
Sarcopenia, characterized by loss of skeletal muscle mass, quality, and strength, has become a common hallmark of ageing and many chronic diseases. Diabetes mellitus patients have a higher prevalence of sarcopenia, which greatly aggravates the ...
The guy below is obviously obese.
I remember reading that BMI charts were a derivative of WWII era height/weight. I'd have to go back to my 6th grade weight to be at a "healthy" BMI.
Some misnomers here. I would watch how you phrase those two. First, carbs aren't the enemy, it's what types of carbs you eat or put into your body. Also, fats aren't the enemy either. Your body doesn't get fat off of fats or the "good fats" anyways. It's always what types of fats are you constantly consuming or carbs you regularly eat. In order to manage weight it's important to know what you put into your body, not necessarily just base it on calories alone.
You have to view obesity as a chronic condition, not an acute disease. You don't get "cured" of obesity like you don't get "cured" of lactose intolerance. It's with you forever. You either "treat" it forever, whether through drugs, lifestyle or a combination, or you have symptoms. Just like some people can lactose intolerance by not eating dairy, others use meds, and others may do both. But if they just stop treating it, it "comes back."
You’re misreading the article. Diabetics are at an increased risk of developing sarcopenia in general. In fact the article specifically mentions that GLP-1 analogs (the drugs we are discussing) can actually be used to reduce sarcopenia risk and see an increase in lean mass.Studies also show a loss in muscle mass and bone density, including an increased risk for sarcopenia.
It doesn't mean people shouldn't use it, especially if obese. But people need to be conscious of the rate at which they are losing weight and make sure to supplement with protein, etc. People also need to be fully educated that if they stop the drug they'll gain the fat back.
Media and doctors are certainly telling people that once off the drugs people tend to gain the weight back. That's true, but that's not really the full story. For most people when they stop they gain the fat back, but not the lost muscle. For most people if you take the drug, then stop, they will end up with a worse body composition then they started with.
There are risks when on it, and most likely it's going to be a drug for life.
Anti‐diabetic drugs and sarcopenia: emerging links, mechanistic insights, and clinical implications - PMC
Sarcopenia, characterized by loss of skeletal muscle mass, quality, and strength, has become a common hallmark of ageing and many chronic diseases. Diabetes mellitus patients have a higher prevalence of sarcopenia, which greatly aggravates the ...www.ncbi.nlm.nih.gov
Yes the drug is a lifetime option currently, but when used combined with exercise specifically weight lifting there is no need to be concerned about muscle loss with proper nutrition as well.
Really good podcast episode talking about the benefits of strength training as you age. They talk about some studies in groups as old as 90, still seeing terrific strength gains.
Since we’re correcting misnomers, care to explain “you body doesn’t get fat off of fats or the good fats anyways” because that is categorically false. Also curious what you’re taking about when differentiating carbs. I have an assumption but don’t like to assume.
Strength training is so important. Even (and especially) for women!
I read recently that fructose causes ATP to be impeded in your cells and makes cravings for fats go up.
I'm not saying what you read was right or wrong. But a few things I've learned to watch for when it comes to health science:
- Studies are usually performed on mice, pigs, chimps, etc. rather than humans. It's assumed that the metabolism of these other animals is the same as in humans, but in many cases that's not a good assumption.
- The papers themselves are usually good about discussing this, but the media that circulates it is not.
- Studies may find "statistically significant" results which are sufficient for publication, but the effect sizes may be too small to have any practical effect.
- The papers themselves are usually good about discussing this, but the media that circulates it is not.
- Even when the above two points are addressed, there is usually a large variation between subjects. IE some people see huge improvements, some people regress, and there's no way to predict where an individual will fall within that range. So maybe you should try it for a while, but if you don't see a big change then it's probably not worthwhile for you in the long run.
My bad - wrong article.
This one shows Ozempic (semaglutide) resulted in loss of fat free mass vs. placebo. Metformin (like the previous article) did not.
Effects of Antidiabetic Drugs on Muscle Mass in Type 2 Diabetes Mellitus - PubMed
Although semaglutide, dapaglifrozin, and canagliflozin have a large weight loss effect, it is important to pay attention to muscle loss because a decrease in FFM was observed.
pubmed.ncbi.nlm.nih.gov
Yeah I should clarify, obviously consuming an excess in calaries of super fatty foods can make you fat, but certain fats are necessary for your diet and some have said can help manage or lower weight. To just say cut out fats is categorically wrong. Look at how unsuccessful or unhealthy the "lowfat/no fat" diets or marketing has done over the years to people. Consuming certain fats can be beneficial and give you the satiety feeling, thus helping in cases of fasting or feelings of fullness in order to not snack or consume excess amounts of food as well as using fat as energy instead of storage. Plus, polyunsaturated fats are good for us, while saturated and trans fats, not so much.
Carbs - just a difference in the types of carbs you put in your body. Simple vs refined. It's as simple as not consuming excess sugar/refined carbs and consume more veggies and fruits. I'm saying quality of carbs and fats make a difference over just saying cut carbs and eat little fat as possible.
Um, my doctor prescribed metformin for my PCOS and insulin resistance. Do you have credentials that make you an expert in these?
