Is Fibromayalga Real?
- Thread starter deadeyededric
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My 29 year old son is still medicated for rapid heart rate and can’t get back much of the weight he lost. Was a perfectly proportioned 165 pounds two and a half years ago and has fought to get back up to 142. Is this what the rest of his life will we like? No one knows, but he feels like his heart is racing frequently.
It's not. But in my lifetime, it has been used far more heavily toward women than toward men.
yep, her RHR was in the 120s, 130s. Dysautonomia.
Recommending to eat a healthy diet when you have unexplained pain is medical advice?
KidSilverhair
Well-Known Member
Yep, I do have sympathy for those suffering from celiac disease or gluten intolerance, but there sure are a lot of people who “self-diagnose” and call themselves one or the other without any kind of medical confirmation. So many conflate “gluten free” with “healthier” without any real understanding of what they’re talking about.
But on the other hand, even if it’s psychosomatic, if a certain diet makes them “feel” better, more power to them, I suppose. It doesn’t effect me at all, so why would I care?
i'm only on page 4 right now, SIAP. but here is some data:
pubmed.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov
Affiliations expand
Affiliations expand
Methods: We acquired functional magnetic resonance imaging and electrocardiography data on FM patients and healthy controls during rest (the rest phase) and during sustained mechanical pressure-induced pain over the lower leg (the pain phase). Functional connectivity associated with different S1 subregions was calculated, while S1(leg) connectivity (representation of the leg in the primary somatosensory cortex) was contrasted between the rest phase and the pain phase and was correlated with clinically relevant measures in FM.
Results: During the rest phase, FM patients showed decreased connectivity between multiple ipsilateral and cross-hemispheric S1 subregions, which was correlated with clinical pain severity. Compared to the rest phase, the pain phase produced increased S1(leg) connectivity to the bilateral anterior insula in FM patients, but not in healthy controls. Moreover, in FM patients, sustained pain-altered S1(leg) connectivity to the anterior insula was correlated with clinical/behavioral pain measures and autonomic responses.
Conclusion: Our study demonstrates that both somatic and nonsomatic dysfunction in FM, including clinical pain, pain catastrophizing, autonomic dysfunction, and amplified temporal summation, are closely linked with the degree to which evoked deep tissue pain alters S1 connectivity to salience/affective pain-processing regions. Additionally, diminished connectivity between S1 subregions during the rest phase in FM may result from ongoing widespread clinical pain.
© 2015 American College of Rheumatology.
Brain imaging in fibromyalgia syndrome - PubMed
Fibromyalgia (FM) is a chronic musculoskeletal pain syndrome which is characterised by clinical pain as well as widespread hyperalgesia/allodynia to mechanical, thermal, electrical, and chemical stimuli. Lack of consistent tissue abnormalities in FM patients has more and more shifted the focus...
pubmed.ncbi.nlm.nih.gov
The somatosensory link in fibromyalgia: functional connectivity of the primary somatosensory cortex is altered by sustained pain and is associated with clinical/autonomic dysfunction - PubMed
Our study demonstrates that both somatic and nonsomatic dysfunction in FM, including clinical pain, pain catastrophizing, autonomic dysfunction, and amplified temporal summation, are closely linked with the degree to which evoked deep tissue pain alters S1 connectivity to salience/affective...
pubmed.ncbi.nlm.nih.gov
Brain imaging in fibromyalgia syndrome
R Staud 1Affiliations expand
- PMID: 22243558
Abstract
Fibromyalgia (FM) is a chronic musculoskeletal pain syndrome which is characterised by clinical pain as well as widespread hyperalgesia/allodynia to mechanical, thermal, electrical, and chemical stimuli. Lack of consistent tissue abnormalities in FM patients has more and more shifted the focus away from peripheral factors and towards central nervous system abnormalities including central sensitisation as well as aberrant pain facilitation and inhibition. Besides quantitative sensory testing, functional brain imaging has been increasingly utilised to characterise the abnormal pain processing of FM patients. Whereas initial work in FM patients identified abnormally increased pain-related brain activity within the thalamus, insula, anterior cingulate, S1, and prefrontal cortex (so-called 'pain matrix'), more recent research focused on altered 'connectivity' between multiple interconnected brain networks in these patients. Additionally, magnetic resonance spectroscopy studies demonstrated high concentration of the excitatory neurotransmitter glutamate in FM patients in pain-related brain areas which correlated not only with experimental but also with clinical pain ratings. Overall, functional brain imaging studies have provided compelling evidence for abnormal pain processing in FM, including brain activity that correlated with patients' augmented pain sensitivity (hyperalgesia/allodynia), temporal summation of pain, and prolonged pain aftersensations. Future imaging work needs to focus on identifying the neural correlates of FM patients' abnormal endogenous pain modulation which will likely not only shed more light on this important pain regulatory mechanism but may also provide useful information for future treatments of FM symptoms.The somatosensory link in fibromyalgia: functional connectivity of the primary somatosensory cortex is altered by sustained pain and is associated with clinical/autonomic dysfunction
Jieun Kim 1 2, Marco L Loggia 1 3, Christine M Cahalan 3, Richard E Harris 4, Florian Beissner Dr Phil Nat 1 5, Ronald G Garcia 1 6, Hyungjun Kim 1 2, Ajay D Wasan 7, Robert R Edwards # 3 8, Vitaly Napadow # 1 3 9Affiliations expand
- PMID: 25622796
- PMCID: PMC4414820
- DOI: 10.1002/art.39043
Abstract
Objective: Fibromyalgia (FM) is a chronic functional pain syndrome characterized by widespread pain, significant pain catastrophizing, sympathovagal dysfunction, and amplified temporal summation for evoked pain. While several studies have demonstrated altered resting brain connectivity in FM, studies have not specifically probed the somatosensory system and its role in both somatic and nonsomatic FM symptoms. Our objective was to evaluate resting primary somatosensory cortex (S1) connectivity and to explore how sustained, evoked deep tissue pain modulates this connectivity.Methods: We acquired functional magnetic resonance imaging and electrocardiography data on FM patients and healthy controls during rest (the rest phase) and during sustained mechanical pressure-induced pain over the lower leg (the pain phase). Functional connectivity associated with different S1 subregions was calculated, while S1(leg) connectivity (representation of the leg in the primary somatosensory cortex) was contrasted between the rest phase and the pain phase and was correlated with clinically relevant measures in FM.
Results: During the rest phase, FM patients showed decreased connectivity between multiple ipsilateral and cross-hemispheric S1 subregions, which was correlated with clinical pain severity. Compared to the rest phase, the pain phase produced increased S1(leg) connectivity to the bilateral anterior insula in FM patients, but not in healthy controls. Moreover, in FM patients, sustained pain-altered S1(leg) connectivity to the anterior insula was correlated with clinical/behavioral pain measures and autonomic responses.
Conclusion: Our study demonstrates that both somatic and nonsomatic dysfunction in FM, including clinical pain, pain catastrophizing, autonomic dysfunction, and amplified temporal summation, are closely linked with the degree to which evoked deep tissue pain alters S1 connectivity to salience/affective pain-processing regions. Additionally, diminished connectivity between S1 subregions during the rest phase in FM may result from ongoing widespread clinical pain.
© 2015 American College of Rheumatology.
The Midwest in general is getting crushed right now with Flu and RSV. My hospital has been at 114% capacity for a little while now. Had a 7 hour wait in the ED and even had someone die in the waiting room, they were resuscitated but avoid the hospitals if you can right now.
Men tend to be less averse to health risk taking - however - they may have fewer care taking responsibilities, easier to do on site stays, whatever and etc. And then as a study coordinator, how do you do a study in a way that removes some of those obstacles.
But that doesn't solve for the fact that you can get female rats just as easily as male rats.
CycloneErik
Well-Known Member
Exactly, anyone can walk into an ER and say they are in pain but are they actually in pain or are they just looking for pills. Thanks to companies like Purdue Pharma and Pfizer, they made pills so addictive that its almost impossible to tell the difference between an addict and a person with real issues. So with someone who thinks they have fibro they are probably in the ER a lot and it shows up on their charts they want pills for pain management.
CycloneErik
Well-Known Member
It's definitely not the catchall some folks want it to be (like our instance here).
Both of my husband’s sisters have been tested and diagnosed with Celiac. They said there is a genetic link so recommended testing our sons. Was almost hoping long haul Covid son had it as people with undiagnosed Celiac have trouble keeping on weight sometimes. All five boys however do not have Celiac.
Between this thread the the Beard thread I feel like I can just skip med and law school and become a Dr Lawyer hybrid. Thanks CF!
The friend I mentioned has diagnosed Celiac's. Decade + ago on that.
If that fails then become an offensive line coach for a football team or an assistant basketball coach that specializes in perfect minute allocations and rotations!
Great point I can become part of the Joe Frog coaching tree.
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