Not the whole class, but close. This didn't happen at ISU, but I had to take a Cell Biology course for my biology degree. The professor, who started teaching this particular course in the year I was born, treated it like biochemistry on steroids. Every exam was just a series of questions asking you to draw out diagrams of things like cell signaling pathways or photosynthesis. You had to draw out all of the molecules involved and their intermediates, label them, and tell what they did. Even if you provided sufficient detail that would comprise an acceptable response for any sane person, be would give you only half of the points. The course was nothing more than rote memorization of excruciatingly detailed diagrams.
Average on the first exam was an F. No curve. Averages on the subsequent exams weren't much better. A non-trivial number of people taking that course from that professor have to repeat it. There are only two reasons why I passed are 1) I scored nearly perfect in the lab portion of the course, which was 20% of the course grade, and 2) the one sliver of leniency shown by this professor was that he did not give +/- grades. Otherwise I would have finished that course with a C- which would have required me to retake it for my degree program.
For the record, I'm a good student with 2 undergrad degrees and I'm about to finish my MS in biology in a few weeks. This was the only C that I have received in the nearly 300 credits of coursework I have taken.