Mizzou- 2 for 1 (played at mizzou last 2 years)
Wisconsin- not a home and home. More like a 3x at madison, 1x at milwaukee situation
Michigan state- not a regular series.
Indiana- not a regular series
OSU- not a regular series
Texas tech- 2 for 1. (played at TTU the last 2 years)
Care to play again?
And even then, how many have two of these regular series set up, like we do with Drake and UNI?
Just going by the premise of the OP: "It's time for Iowa State to only play this game at home, at Wells Fargo, or else not at all."