As far as sports goes, the simplest options would be to make separate leagues or have advantaged individuals compete with their birth sex to negate that advantage. Separate league would probably be easier to implement.
I would LOVE an open league where any performance enhancing substances were "allowed" ala professional body building. I think there will always be a market for the "pure" sports vision, and I know there's a market for all the after-market enhancements you can stomach in whatever athletic endeavor you want.