ISU has had a problem with QBs and receivers throughout the entirety of Rhoads's tenure. Between them, they just don't consistently make enough plays to sustain drives. Drops, bad throws, bad routes, misreads, can't hold a two second block on a bubble screen, whatever.
TCU and BU make those plays. The vast majority of throws are close enough for the receiver to make a play, and most (when designed to do so) hit the receiver in stride so he can make yards after the catch. The receivers don't drop balls that are right on target. The receivers finish the tough receptions. The bigger receiver destroys the smaller DB on the bubble screen. Other teams in the Big 12 are consistent too, but not quite to the level of TCU and BU.
IMO, ISU just doesn't coach those positions well. And I'm sure talent and athleticism play into it as well. Whatever it is, it has got to be fixed. The Big 12 is about scoring. Score or perish...